A Detail Overview On Viagra Enhancement Pills:

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One of a very useful supplement named Flibanserin (Addyi), also like Viagra drug, it has been approved by the Food and Drug Administration (FDA) in the treatment of female sexual interest and arousal disorder {FSIAD (FSIAD is also known as hypoactive sexual desire disorder)} in premenopausal women.
Hypoactive sexual desire disorder (HSDD). Female sexual arousal disorder.

The Addyi is now only available through certain pharmacies and prescribers. The Addyi prescribed approved by the providers which are in agreement between the manufacturer and the FDA. To meet certain FDA requirements a prescriber must be certified by the manufacturer. It’s taken once/day, before going to bed.

Addyi vs Viagra

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On the other hand, the FDA has not approved Viagra (sildenafil) itself for women to use it. Because it has been prescribed off label for the women who have a low sex drive.

 

 

OFF-LABEL DRUG USE

Off label mean that a drug that is approved by the FDA for one purpose is also used for the other different purpose and that has not been approved yet.
The evidence of female Viagra’s effectiveness is mixed at best. A female Viagra review trusted Source of trials in the women conjecture that positive results are notie in regard to physical arousal. So, however, this is not the case for the more nature complex of FSIAD.

For example, a detail female Viagra review of a study that gave 202 postmenopausal women with primary FSIAD to Viagra.

Researchers observed an increased amount of vaginal lubrication, orgasm and arousal (how to increase female arousal) sensations in study participants. However, the women with secondary FSIAD associated disorders including (such as diabetes and multiple sclerosis (MS)) reported no increase in enjoyment or desire.

One more second study discussed in the female Viagra review found that both postmenopausal and premenopausal women described not a single significant positive response when they using Viagra dosage.

Benefit and Purpose

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There are so many reasons that women would ferret out the strongest Viagra pill. As an approach of middle age and beyond, to observe a decrease in their overall sex drive and its not uncommon for women.

A decrease in sex drive, it can also arise from daily significant life events, stressors, or chronic conditions such as diabetes and MS.

So on the other side, however, some of the women observe an absence or decrease in sex drive due to FSIAD. According to one review from an expert panel, FSIAD is estimated to affect adult women by about 10%.

It’s characterized by the following symptoms:

Absent or limited sexual fantasies or thoughts
Absent or reduced response of desire to sexual stimulation or cues
Inability or loss of interest to maintain interest in sexual activities
The significant feeling of incompetence, frustration, or worry at the lack of sexual arousal or interest.

Flibanserin how its work:
Flibanserin was originally known and developed as an antidepressant, but it was approved by the FDA for the treatment of FSIAD in the year 2015.

It’s known that taking flibanserin regularly raises levels of dopamine and norepinephrine in the body. At the same time, it lowers levels of serotonin.

How to increase female arousal and desire:
Both norepinephrine and dopamine are more significant for sexual excitement. Dopamine has a role in boosting sexual desire. Norepinephrine has a role in promoting sexual arousal.

Effectiveness

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The FDA approval of flibanserin was based on the results of three phases III clinical trials. Each trial lasted 24 weeks and evaluated the efficacy of flibanserin compared to a placebo in premenopausal women.

The investigators and the FDA analyzed the results of the three trials. When adjusted for placebo response, about 10 percent trusted Source of participants reported a “much improved” or “very much improved” status in trial weeks 8 to 24. This is a modest improvement when compared to Viagra.

A review published three years after Viagra’s FDA approval for treating erectile dysfunction (ED) summarizes the worldwide responses to treatment. In the United States, for example, 74 percent of trusted sources of participants responded positively. That is compared to a 19 to 20% of positive responses for those who take a placebo.

In Postmenopausal women
Flibanserin isn’t FDA-approved for use in postmenopausal women. However, the efficacy of flibanserin in this population was assessed in a single trial.

The resultsTrusted Source was reported as similar to those reported in premenopausal women. This will need to be replicated in additional trials for it to be approved for postmenopausal women.

Side effects
The most common side effects of flibanserin include:

Nausea
Dizziness
Dry mouth
Tiredness
Fainting or loss of consciousness
Difficulty falling asleep or remaining asleep
Low blood pressure, also known as hypotension

FDA warnings: On liver disease, enzyme inhibitors, and alcohol
This drug has boxed warnings. These are the most serious warnings from the Food and Drug Administration (FDA). A boxed give (warning alerts) to patients and doctors about the effects of the drug that may be dangerous for health.
Flibanserin (Addyi) can cause fainting or severe hypotension when taken by people with liver disease or alongside certain drugs, including alcohol.
You shouldn’t use Addyi if you take certain moderate or strong CYP3A4 inhibitors. This group of enzyme inhibitors includes select antibiotics, antifungals, and HIV medications, as well as other types of drugs. Grapefruit juice is also a moderate CYP3A4 inhibitor.
To prevent these side effects, you should also refrain from drinking alcohol for at least two hours before taking your nightly dose of Addyi. After you take your dose, you should refrain from drinking alcohol until the next morning. If you’ve consumed alcohol less than two hours before your anticipated bedtime, you should skip that night’s dose instead.

Warnings and interactions
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Flibanserin shouldn’t be used in people with liver problems.

You must communicate with your doctor about what supplements and medications you are taking before beginning of flibanserin. You also shouldn’t take flibanserin if you’re taking any of the following medications or supplements:

certain medications used to treat cardiovascular conditions, such as diltiazem (Cardizem CD) and verapamil (Verelan)
certain antibiotics, such as ciprofloxacin (Cipro) and erythromycin (Ery-Tab)
medications to treat fungal infections, such as fluconazole (Diflucan) and itraconazole (Sporanox)
HIV medications, such as ritonavir (Norvir) and indinavir (Crixivan)
nefazodone, an antidepressant
supplements such as St. John’s wort
Many of these drugs belong to a group of enzyme inhibitors known as CYP3A4 inhibitors.

Lastly, you shouldn’t drink grapefruit juice while taking flibanserin. It’s also a CYP3A4 inhibitor.

Addyi and alcohol

When Addyi was first FDA-approved, the FDA warned those using the drug to abstain from alcohol due to the risk of fainting and severe hypotension. However, the FDA updated its warning on alcohol rushed Source in April 2019.

If you’re prescribed Addyi, you no longer have to avoid alcohol completely. However, after you take your nightly dose, you should refrain from drinking alcohol until the next morning.

You should also refrain from drinking alcohol for at least two hours before taking your nightly dose. If you’ve consumed alcohol less than two hours before your anticipated bedtime, you should skip that night’s dose of Addyi instead.

If you miss a dose of Addyi for any reason, don’t take a dose to make up for it the next morning. Wait until the next evening and resume your regular dosing schedule.

Challenges of approval

e to make up for it the next morning. Wait until the next evening and resume your regular dosing schedule.

Flibanserin had a challenging path to FDA approval.

The FDA reviewed the drug three times before approving it. There were concerns about its efficacy when compared with negative side effects. These concerns were the main reasons why the FDA recommended against approval after the first two reviews.

There were also lingering questions regarding how female sexual dysfunction should be treated. Sex drive is quite complex. There’s both a physical and a psychological component.

Flibanserin and sildenafil work in different ways. Sildenafil, for example, doesn’t increase sexual arousal in men. On the other hand, flibanserin works to raise levels of dopamine and norepinephrine to promote desire and arousal.

One strong Viagra pill targets on a physical aspect of sexual dysfunction. The other targets the feelings of arousal and desire, a more complicated issue.

Following a third review, the FDA approved the drug due to unmet medical needs. However, concerns still remained regarding side effects. Very severe hypotension observed when they are taken flibanserin with alcohol.

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The Takeaway
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There are many causes of low sex drive, ranging from everyday stressors to FSIAD.

Does Viagra make you last longer? However, basically viagra has seen mixed results in women in general, and it hasn’t been found effective for women with FSIAD. Premenopausal women with FSIAD may feel a strong and effective improvement in arousal and desire after taking Addyi.

First, you must be suggested to your doctor if you’re interested in taking Viagra and addyi. Also, be sure to discuss your other medications or supplements with your doctor before using Viagra and addyi.

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